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Daniel Simon Co-design Approaches to Dependable Networked Control Systems


This book describes co-design approaches, and establishes the links between the QoC (Quality of Control) and QoS (Quality of Service) of the network and computing resources. The methods and tools described in this book take into account, at design level, various parameters and properties that must be satisfied by systems controlled through a network. Among the important network properties examined are the QoC, the dependability of the system, and the feasibility of the real-time scheduling of tasks and messages. Correct exploitation of these approaches allows for efficient design, diagnosis, and implementation of the NCS. This book will be of great interest to researchers and advanced students in automatic control, real-time computing, and networking domains, and to engineers tasked with development of NCS, as well as those working in related network design and engineering fields.

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Harald Gossner System Level ESD Co-Design


An effective and cost efficient protection of electronic system against ESD stress pulses specified by IEC 61000-4-2 is paramount for any system design. This pioneering book presents the collective knowledge of system designers and system testing experts and state-of-the-art techniques for achieving efficient system-level ESD protection, with minimum impact on the system performance. All categories of system failures ranging from 'hard' to 'soft' types are considered to review simulation and tool applications that can be used. The principal focus of System Level ESD Co-Design is defining and establishing the importance of co-design efforts from both IC supplier and system builder perspectives. ESD designers often face challenges in meeting customers' system-level ESD requirements and, therefore, a clear understanding of the techniques presented here will facilitate effective simulation approaches leading to better solutions without compromising system performance. With contributions from Robert Ashton, Jeffrey Dunnihoo, Micheal Hopkins, Pratik Maheshwari, David Pomerenke, Wolfgang Reinprecht, and Matti Usumaki, readers benefit from hands-on experience and in-depth knowledge in topics ranging from ESD design and the physics of system ESD phenomena to tools and techniques to address soft failures and strategies to design ESD-robust systems that include mobile and automotive applications. The first dedicated resource to system-level ESD co-design, this is an essential reference for industry ESD designers, system builders, IC suppliers and customers and also Original Equipment Manufacturers (OEMs). Key features: Clarifies the concept of system level ESD protection. Introduces a co-design approach for ESD robust systems. Details soft and hard ESD fail mechanisms. Detailed protection strategies for both mobile and automotive applications. Explains simulation tools and methodology for system level ESD co-design and overviews available test methods and standards. Highlights economic benefits of system ESD co-design.

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Daniel Simon Trekking Bike

Daniel Alazard Reverse Engineering in Control Design


Reverse Engineering in Control Design proposes practical approaches to building a standard H-infinity problem taking into account an initial controller. Such approaches allow us to mix various control objectives and to initialize procedures for a fixed-structure controller design. They are based on the Observer-Based Realization (OBR) of controllers. The interest of OBR from the controller implementation point of view is detailed and highlighted in this book through academic examples. An open-source toolbox is available to implement these approaches in Matlab®. Throughout the book academic applications are proposed to illustrate the various basic principles. These applications have been chosen by the author for their pedagogic contents and demo files and embedded Matlab® functions can be downloaded so readers can run these illustrations on their personal computers. Contents 1. Observer-based Realization of a Given Controller. 2. Cross Standard Form and Reverse Engineering. 3. Reverse Engineering for Mechanical Systems. Appendix 1. A Preliminary Methodological Example. Appendix 2. Discrete-time Case. Appendix 3. Nominal State-feedback for Mechanical Systems. Appendix 4. Help of Matlab® Functions. About the Authors Daniel Alazard is Professor in System Dynamics and Control at Institut Supérieur de l'Aéronautique et de l’Espace (ISAE), Toulouse, France – SUPAERO Graduate Program. His main research interests concern robust control, flexible structure control and their applications to various aerospace systems.

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Daniel Simon Bike & Wellness in den Alpen

Rense Corten Computational Approaches to Studying the Co-evolution of Networks and Behavior in Social Dilemmas


Computational Approaches to Studying the Co-evolution of Networks and Behaviour in Social Dilemmas shows students, researchers, and professionals how to use computation methods, rather than mathematical analysis, to answer research questions for an easier, more productive method of testing their models. Illustrations of general methodology are provided and explore how computer simulation is used to bridge the gap between formal theoretical models and empirical applications.

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Группа авторов Robust Control Design: An Optimal Control Approach


Comprehensive and accessible guide to the three main approaches to robust control design and its applications Optimal control is a mathematical field that is concerned with control policies that can be deduced using optimization algorithms. The optimal control approach to robust control design differs from conventional direct approaches to robust control that are more commonly discussed by firstly translating the robust control problem into its optimal control counterpart, and then solving the optimal control problem. Robust Control Design: An Optimal Control Approach offers a complete presentation of this approach to robust control design, presenting modern control theory in an concise manner. The other two major approaches to robust control design, the H_infinite approach and the Kharitonov approach, are also covered and described in the simplest terms possible, in order to provide a complete overview of the area. It includes up-to-date research, and offers both theoretical and practical applications that include flexible structures, robotics, and automotive and aircraft control. Robust Control Design: An Optimal Control Approach will be of interest to those needing an introductory textbook on robust control theory, design and applications as well as graduate and postgraduate students involved in systems and control research. Practitioners will also find the applications presented useful when solving practical problems in the engineering field.

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Группа авторов This is Service Design Thinking


This is Service Design Thinking introduces an inter-disciplinary approach to designing services. Service design is a bit of a buzzword these days and has gained a lot of interest from various fields. This book, assembled to describe and illustrate the emerging field of service design, was brought together using exactly the same co-creative and user-centred approaches you can read and learn about inside. The boundaries between products and services are blurring and it is time for a different way of thinking: this is service design thinking. A set of 23 international authors and even more online contributors from the global service design community invested their knowledge, experience and passion together to create this book. It introduces service design thinking in manner accessible to beginners and students, it broadens the knowledge and can act as a resource for experienced design professionals. Besides an introduction to service design thinking through five basic principles, a selection of individual perspectives demonstrate the similarities and differences between various disciplines involved in the design of services. Additionally, the book outlines an iterative design process and showcases 25 adaptable service design tools, exemplifying the practice of service design with five international case studies. The book concludes with an insight into the current state of service design research and sets service design thinking in a philosophical context. In collaboration with: (in alphabetical order) Kate Andrews (UK), Beatriz Belmonte (E), Ralf Beuker (GER), Fergus Bisset (UK), Kate Blackmon (UK), Johan Blomkvist (SE), Simon Clatworthy (NO), Lauren Currie (UK), Sarah Drummond (UK), Jamin Hegeman (USA), Stefan Holmlid (SE), Luke Kelly (NL), Lucy Kimbell (UK), Satu Miettinen (FI), Asier Pérez (E), Bas Raijmakers (NL), Jakob Schneider (GER), Fabian Segelström (SE), Marc Stickdorn (A), Renato Troncon (IT), Geke van Dijk (NL), Arne van Oosterom (NL), Erik Widmark (S)

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Terri Peters Design for Health. Sustainable Approaches to Therapeutic Architecture


Design for Health: Sustainable Approaches to Therapeutic Architecture Guest-Edited by Terri Peters This issue of AD seeks out innovative and varied sustainable architectural responses to designing for health, such as: integrating sensory gardens and landscapes into the care environment; specifying local materials and passive technologies; and reinvigorating aging postwar facilities. Contributors include: Anne-Marie Adams, Sean Ahlquist, Giuseppe Boscherini, Robin Guenther, Charles Jencks, Richard Mazuch, Stephen Verderber, Featured architects: 100% Interior, Arup, C.F. Møller, Lyons, MASS Design Group, Mongomery Sisam Architects, Penoyre & Prasad

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Heinz-Bernhard Kraatz Kinomics. Approaches and Applications


Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.

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Daniel Simon

Film Design. Tron Legacy. product design. lotus c-01 Concept. film design. oblivion

Daniel Simon ® | Roborace

— Daniel Simon, Chief Design Officer Roborace. MAKING . The Robocar is being continuously tested and developed in the UK. It had a first public track outing during the Formula E-Prix in Paris 2016, during which it performed a single low speed lap. It has been on public display worldwide, such as in London, New York, Frankfurt, Munich, Monaco, Detroit, and Las Vegas. To engage the public in ...

Daniel Simon - Startseite | Facebook

Daniel Simon. Gefällt 70.436 Mal. Iconic designs for brands like Bugatti, Lotus, Tron, SpaceX, F1. Creator of Cosmic Motors & The Timeless Racer. Sharing news and thoughts.

Top 5 Daniel Simon Designs | CarBuzz

An automotive futurist, Hollywood consultant and one-time Bugatti designer, Daniel Simon has emerged as a visionary when it comes to styling cars for this world and others. Never heard of Daniel...

Daniel Simon: Conceptual Designer and Automotive Futurist ...

Daniel Simon, to be brief, started his career off in Volkswagen design studio before becoming disillusioned with the auto industry, or, more specifically, the machine that makes the auto industry the big lumbering behemoth that takes forever to change direction and make decisions. Sometimes resulting in very bad decisions. So Simon decided to hop on a plane and head to Brazil where he spent ...

Daniel Simon – dasauge® Designer

Daniel Simon ist bei dasauge®. Handlettering, Logodesign, CD, Typo, Editorial Design in Delmenhorst. Logo, Handlettering, Lettering, Kalligrafie

Daniel Simon - Wikipedia

Daniel Simon (born 1975) is a German concept designer and automotive futurist. He is best known for his vehicle designs in movies like Tron: Legacy and Oblivion, and his book Cosmic Motors.

Daniel Simon ® | About

DANIEL SIMON Founder & President Daniel Simon ® LLC . Daniel describes his work as a disruptive fusion of automotive styling, innovative engineering, and world-building aspiration, summarized as ‘Style for all Galaxies’. The results are vehicles for the present, the future, and imagined pasts. The concepts are always original, yet radiate a strategic familiarity and logic. With an ...

Daniel Simon | GfG | Agentur aus Bremen

Daniel Simon . Grafik, Corporate und Editorial Design. Bei der GfG seit: 2018. Das Beste an deinem Job: Dass ich meine Leidenschaft zu meinem Beruf machen konnte . Du bist in der Agentur berüchtigt für: Meine Handletterings und Isometriegrafiken. Die besten Ideen kommen dir: Auf dem Fahrrad und unter der Dusche. Form oder Funktion, was zuerst: Ich fokussiere mich gerne auf die Form, um den ...

Daniel - SimFans.de

Ich bin Daniel und als Gründer von SimFans.de seit 2004 aktiv in der Die Sims-Community. Ich bin im Bau-Modus zu Hause und liebe es durch meine Videos mit der Community in Kontakt zu treten. Ich koordiniere das Team, bin primär auf YouTube zu Hause, beschäftige mich gerne kreativ mit der Gestaltung der Website und bin sonst das Mädchen für alles.

10+ Best Daniel Simon images | concept design, industrial ...

Oct 18, 2014 - Explore Young Ahn's board "Daniel Simon" on Pinterest. See more ideas about Concept design, Industrial design sketch, Concept art.

Die 34 besten Bilder zu Daniel Simon in 2020 | Fahrzeuge ...

Daniel Simon is a German concept designer and automotive futurist best known for his own brand Cosmic Motors™. Cosmic Motors is a fantasy Sportwagen Rennwagen Zukunftstechnologie Konzeptfahrzeuge Transportmittel Motorräder Daniel Simon concept for Cosmic Motors

Daniel Simon – Wikipedia

Daniel Simon ist der Name folgender Personen: . Daniel Simon (Dichter) (* 1967), US-amerikanischer Dichter, Übersetzer und Journalist Daniel Simon (Designer) (* 1975), deutscher Automobildesigner Daniel Simon (Schwimmer) (* 1988), deutscher Schwimmer Diese Seite wurde zuletzt am 21. Juli 2020 um 19:19 Uhr bearbeitet.

Inside the mind of Roborace car designer Daniel Simon ...

Droid rage: inside the mind of Roborace concept car designer Daniel Simon By Dominic Bliss 14 December 2019 Daniel Simon designs the autonomous all-electric cars for the Roborace series.

Daniel Simon: Conceptual Designer and Automotive Futurist ...

Aug 13, 2019 - We interview visionary designer Daniel Simon in his California home to discuss his latest book, The Timeless Racer, and find out what makes him who he is. Daniel Simon is a designer’s God. His ability to imagine and create vehicles in otherworldly environments is incredible; he has an amazingly masterful grasp of desig…

The clean yet intimidating Drone from the movie 'Oblivion ...

Feb 16, 2017 - The clean yet intimidating Drone from the movie 'Oblivion'. Concept design by Daniel Simon.

Daniel Simon – System Design Responsible for Mission ...

Daniel Simon System Design Responsible for Mission Equipments at Airbus Helicopters München und Umgebung, Deutschland 329 Kontakte

Daniel Simon in Berlin bei XING: 6 Personen | XING

Daniel Simon: Finde 6 Mitglieder in Berlin und weiteren Städten, inkl. Kontaktdaten und weiteren Informationen – direkt bei XING!

Daniel Simon on Behance

Daniel is always looking for the next cool machine to design. Join the entertaining journey here on Behance! Experiences include: Senior Designer at Bugatti & Volkswagen; Vehicle Designer on Tron: Legacy, Ridley Scott's Prometheus, Oblivion; Writer and Creator of Cosmic Motors & The Timeless Racer.

143 Best DanielSimon images in 2020 | Car design, Concept ...

May 19, 2020 - Explore Bogdan Zaha's board "DanielSimon", followed by 457 people on Pinterest. See more ideas about Car design, Concept design, Concept cars.

Daniel Simon in der XING Personensuche finden | XING

Finde 122 Profile von Daniel Simon mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING.

daniel simon - Google Search | Autodesign, Produktdesign ...

28.03.2015 - Aniket Das hat diesen Pin entdeckt. Entdecke (und sammle) deine eigenen Pins bei Pinterest.

Daniel Simon – Country Manager Germany / VP Global Sales ...

Sehen Sie sich das Profil von Daniel Simon auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. 7 Jobs sind im Profil von Daniel Simon aufgelistet. Sehen Sie sich auf LinkedIn das vollständige Profil an. Erfahren Sie mehr über die Kontakte von Daniel Simon und über Jobs bei ähnlichen Unternehmen.

Daniel Simon (@danielsimondesign) • Instagram photos and ...

47.9k Followers, 365 Following, 1,145 Posts - See Instagram photos and videos from Daniel Simon (@danielsimondesign)

Daniel Simon Profile | Facebook

Profile von Personen mit dem Namen Daniel Simon anzeigen. Tritt Facebook bei, um dich mit Daniel Simon und anderen Personen, die du kennen könntest, zu...

Daniel Simon: Conceptual Designer and Automotive Futurist ...

Daniel Simon is a designer's God. Blessed with talent, he worked for Volkswagen in Wolfsburg and Barcelona before giving up the car industry to move to Brazi...

100+ Best Daniel Simon images | concept cars, concept ...

Mar 28, 2015 - Explore Keith Hall's board "Daniel Simon", followed by 560 people on Pinterest. See more ideas about Concept cars, Concept design, Concept art.

Interview with designer Daniel Simon (Part 2) - YouTube

Inspiration, racing and Italian style; the second of our two-part interview with conceptual designer and automotive futurist Daniel Simon Watch Part 1 here: ...

Daniel Simon Boat design (With images) | Boat design ...

Aug 4, 2014 - This Pin was discovered by Kevin Smit. Discover (and save!) your own Pins on Pinterest

Daniel Simons -- Home Page

Daniel. Simons. HOME. BLOG. ABOUT DAN. WRITING. SPEAKING. RESEARCH. VIDEOS. CONTACT. Welcome to my personal website. I am a professor in the Department of Psychology at the University of Illinois. My research explores the limits of our own minds and the reasons why we often are unaware of our limits. I have taught introductory psychology as well as seminars/courses in visual cognition. I ...

Daniel Simon – The Curb Shop

Daniel Simon is a passionate car and film designer, with roots at Bugatti and Volkswagen. He settled in sunny California, where he focuses on developing advanced vehicles for industries and movies, such as Tron: Legacy, Prometheus, Oblivion, and Star Wars: The Last Jedi. He is Chief Design Officer at Roborace, and deputy designer at Singer Vehicle Design.

Infographics , UI Design et Web Design - Daniel Simon ...

Infographics , UI Design et Web Design : – Picture : Facebook Twitter Google+ Pinterest – Description Daniel Simon Vehicle Design — Designspiration -Read More –

1,000+ "Daniel Simon" profiles | LinkedIn

View the profiles of professionals named "Daniel Simon" on LinkedIn. There are 1,000+ professionals named "Daniel Simon", who use LinkedIn to exchange information, ideas, and opportunities.

by Daniel Simon | Concept ships, Helicopter, Aircraft design

Apr 19, 2016 - design, product, trend, inspiration and plllus!

Daniel Simon, Author at Schlenter & Simon Software

Daniel Simon 11.03.2012 10:10 11.08.2017 Katharina Molzberger ist eine talentierte und junge Schauspielerin, die für ihre Karriere eine Website zu Präsentationszwecken benötigte. Die Künstlerin suchte nicht nur eine Umsetzung eines vorgegebenen Designs, sondern eine Komplettlösung, angefangen beim Webdesign bis hin zur Implementierung und Schulung.

Daniel Simon Profiles | Facebook

View the profiles of people named Daniel Simon. Join Facebook to connect with Daniel Simon and others you may know. Facebook gives people the power to...

Daniel Simon - Hlavní stránka | Facebook

Daniel Simon. 70 tis. To se mi líbí. Iconic designs for brands like Bugatti, Lotus, Tron, SpaceX, F1. Creator of Cosmic Motors & The Timeless Racer. Sharing news and thoughts.

Daniel Simon, CCO & Creative Leader | Aperto

Daniel Simon. CCO Daniel Simon Voriger. Nächster# Creative Leader. Daniel has been on the Aperto board of directors as CCO since 2014. As creative strategist and transformer he is responsible for the brand, communication and creation spheres. The father of three daughters perfected his competencies as a founder of several agencies, among them the creative agency PLANTAGE BERLIN in 2001 ...

Daniela Simon im Das Telefonbuch - Jetzt finden!

ll Daniela Simon gesucht? Richtige Adressen und Telefonnummern finden! 43 Einträge zu Daniela Simon mit aktuellen Kontaktdaten, Öffnungszeiten und Bewertungen ☎ Das Telefonbuch - Ihre Nr. 1 für Adressen und Telefonnummern

Daniel Simon - m.facebook.com

Daniel Simon. 70K likes. Iconic designs for brands like Bugatti, Lotus, Tron, SpaceX, F1. Creator of Cosmic Motors & The Timeless Racer. Sharing news and thoughts.

Daniel Simon im Das Telefonbuch - Jetzt finden!

3 Ein Service der competence data GmbH & Co. KG; 4 Ein Service der Rudolf Röser Verlag und Informationsdienste AG; 5 Ein Service Ihres Verlages Das Telefonbuch in Kooperation mit agendize; 6 Ein Service Ihres Verlages Das Telefonbuch in Kooperation mit timify; D.S. Bautenschutz Daniel Simon Bautenschutz 3io F zqqd ehr vzm sw nv7 eg 501 5 2, 3 64 0 49 6 17 5 5 H 3rh an f8xq no 6 v hl0 er ...

Sports Brand Identity Development | Studio Simon | United ...

Sports Brand Identity Development | Studio Simon. STUDIO SIMON. WORK. ABOUT. CONTACT. PRESS. More. Studio Simon offers an unprecedented confluence of full-service sports branding capabilities, proven success and award-winning creativity. Address. 2815 Taylorsville Road. Suite 212. Louisville, KY 40205. 502-479-8447. Get in Touch. Submit. Thanks! We'll get back to you shortly. LET’S TEAM UP ...

My respect to Daniel Simon on Behance | Truck design ...

Jun 14, 2018 - This Pin was discovered by Liqinmeng. Discover (and save!) your own Pins on Pinterest

Daniel Simon - Startside | Facebook

Daniel Simon. 70 tusind Synes godt om. Iconic designs for brands like Bugatti, Lotus, Tron, SpaceX, F1. Creator of Cosmic Motors & The Timeless Racer. Sharing news and thoughts.

Daniel Simon D.S. Bautenschutz, Hannover - Firmenauskunft

Daniel Simon D.S. Bautenschutz mit Sitz in Hannover ist in der Creditreform Firmendatenbank mit der Rechtsform Gewerbebetrieb eingetragen. Das Unternehmen ist wirtschaftsaktiv. Das Unternehmen wird derzeit von einem Manager (1 x Inhaber) geführt. Die Steuernummer des Unternehmens ist in den Firmendaten verfügbar. Das Unternehmen verfügt über einen Standort. Sie erreichen das Unternehmen ...

Daniel Simon Böttger | OSC Cyclingteam

Daniel Simon Böttger . News. Herzlichen Glückwunsch. Unser Denny ist zum 2. mal Papa geworden, seine Frau brachte heute eine gesunde Tochter (53cm und 3530 Gramm) auf die Welt. Wir gratulieren den Eltern und wünschen alles Gute. PS: Denny wir werden Dich auf dem Rad vermissen. Lesen . Spannende Paarungen. Die 2. OSC-Cyclingteam Corona Challenge ist seit gestern Geschichte und mit 14 Paaren ...

Daniel M. Simon | People | DLA Piper Global Law Firm

Daniel Simon concentrates his practice on corporate restructuring and bankruptcy. Daniel has been actively involved in numerous complex restructuring and acquisition matters on behalf of the firm's clients, with a particular emphasis in the oil and gas, retail, health care, medical services, technology and other industries. Daniel has extensive experience counseling clients on strategic ...

Daniel Simon - IMDb

Daniel Simon, Art Department: Oblivion. Daniel Simon is known for his work on Oblivion (2013), Captain America: The First Avenger (2011) and Star Wars: Episode VIII - The Last Jedi (2017).

| Boutique en ligne Daniel Hechter

Daniel Hechter. An successful story, since more than 50 years 1962 The brand is created by designer DANIEL HECHTER 1968 The First DANIEL HECHTER men's collection 1970 Sponsorship engagement with PSG – beginning of extensive sponsorship activities 1998 The DANIEL HECHTER brand is acquired by Aulbach Group

Daniel Simon - COO - Activist Investing LLC | LinkedIn

View Daniel Simon’s profile on LinkedIn, the world's largest professional community. Daniel has 3 jobs listed on their profile. See the complete profile on LinkedIn and discover Daniel’s ...

Stufflebeam Daniel L. Evaluation Theory, Models, and Applications


The golden standard evaluation reference text Now in its second edition, Evaluation Theory, Models, and Applications is the vital text on evaluation models, perfect for classroom use as a textbook, and as a professional evaluation reference. The book begins with an overview of the evaluation field and program evaluation standards, and proceeds to cover the most widely used evaluation approaches. With new evaluation designs and the inclusion of the latest literature from the field, this Second Edition is an essential update for professionals and students who want to stay current. Understanding and choosing evaluation approaches is critical to many professions, and Evaluation Theory, Models, and Applications, Second Edition is the benchmark evaluation guide. Authors Daniel L. Stufflebeam and Chris L. S. Coryn, widely considered experts in the evaluation field, introduce and describe 23 program evaluation approaches, including, new to this edition, transformative evaluation, participatory evaluation, consumer feedback, and meta-analysis. Evaluation Theory, Models, and Applications, Second Edition facilitates the process of planning, conducting, and assessing program evaluations. The highlighted evaluation approaches include: Experimental and quasi-experimental design evaluations Daniel L. Stufflebeam's CIPP Model Michael Scriven's Consumer-Oriented Evaluation Michael Patton's Utilization-Focused Evaluation Robert Stake's Responsive/Stakeholder-Centered Evaluation Case Study Evaluation Key readings listed at the end of each chapter direct readers to the most important references for each topic. Learning objectives, review questions, student exercises, and instructor support materials complete the collection of tools. Choosing from evaluation approaches can be an overwhelming process, but Evaluation Theory, Models, and Applications, Second Edition updates the core evaluation concepts with the latest research, making this complex field accessible in just one book.

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Buchwald Peter Retrometabolic Drug Design and Targeting


Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

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Simon Van Booy Wszystko, co piękne, zaczęło się potem

Paul Simon Paul Simon - Stranger To Stranger

Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future


A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

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Группа авторов Message Communication Arts Research


Mapping Eclecticism Through Practice brings together a range of graphic design  practices and approaches that include the use of socially responsible design and persuasion, as well as collaboration with other disciplines, to improve safety; framing theory and ideograms within architectural pedagogy to convey complex ideas and relationships; literary analysis to explore graphic design authorship, narrative and viewer experience; discursive dialogue and a non-linear presentation to interrogate and shed light on personal practice; and cartographic metaphors as a means of visualising and investigating the topography of graphic design.

616.65 RUR

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Brian Wood J.B. Building Care


Building care encompasses everything from maintenance of a building to energy conservation and range of approaches, including the effects on design. A range of approaches to looking after buildings and their users is covered in this book. The rationale and conditions that support them (e.g. PPM – preventative planned maintenance; JIT – just in time) are explained, together with the commercial and environmental imperatives driving new approaches to building care.

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Nan Zheng Learning in Energy-Efficient Neuromorphic Computing: Algorithm and Architecture Co-Design


Explains current co-design and co-optimization methodologies for building hardware neural networks and algorithms for machine learning applications This book focuses on how to build energy-efficient hardware for neural networks with learning capabilities—and provides co-design and co-optimization methodologies for building hardware neural networks that can learn. Presenting a complete picture from high-level algorithm to low-level implementation details, Learning in Energy-Efficient Neuromorphic Computing: Algorithm and Architecture Co-Design also covers many fundamentals and essentials in neural networks (e. g. , deep learning), as well as hardware implementation of neural networks. The book begins with an overview of neural networks. It then discusses algorithms for utilizing and training rate-based artificial neural networks. Next comes an introduction to various options for executing neural networks, ranging from general-purpose processors to specialized hardware, from digital accelerator to analog accelerator. A design example on building energy-efficient accelerator for adaptive dynamic programming with neural networks is also presented. An examination of fundamental concepts and popular learning algorithms for spiking neural networks follows that, along with a look at the hardware for spiking neural networks. Then comes a chapter offering readers three design examples (two of which are based on conventional CMOS, and one on emerging nanotechnology) to implement the learning algorithm found in the previous chapter. The book concludes with an outlook on the future of neural network hardware. Includes cross-layer survey of hardware accelerators for neuromorphic algorithms Covers the co-design of architecture and algorithms with emerging devices for much-improved computing efficiency Focuses on the co-design of algorithms and hardware, which is especially critical for using emerging devices, such as traditional memristors or diffusive memristors, for neuromorphic computing Learning in Energy-Efficient Neuromorphic Computing: Algorithm and Architecture Co-Design is an ideal resource for researchers, scientists, software engineers, and hardware engineers dealing with the ever-increasing requirement on power consumption and response time. It is also excellent for teaching and training undergraduate and graduate students about the latest generation neural networks with powerful learning capabilities.

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Gisbert Schneider De novo Molecular Design


Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

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Группа авторов Environmentally Responsible Design


At last, there's an authoritative guide to help interior designers apply green- building and sustainability applications to their environments. Sustainable Interior Design expertly introduces the principles of environmentally responsible design for interior environments. This useful reference provides beginning designers and experienced professionals alike with a comprehensive survey that coverers everything from theoretical approaches to current practices. It helps designers understand the environmentally responsible approach and make design decisions that are ethical and do not harm the world?s environment.

8335.22 RUR

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